Prioritization of anticancer drugs against a cancer using genomic features of cancer cells: A step towards personalized medicine

posted Mar 31, 2016, 11:50 PM by Geetha Sugumaran   [ updated Apr 1, 2016, 3:52 AM ]
In this study, we investigated drug profile of 24 anticancer drugs tested against a large number of cell lines in order to understand the relation between drug resistance and altered genomic features of a cancer cell line. We detected frequent mutations, high expression and high copy number variations of certain genes in both drug resistant cell lines and sensitive cell lines. It was observed that a few drugs, like Panobinostat, are effective against almost all types of cell lines, whereas certain drugs are effective against only a limited type of cell lines. 
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