Anti-HIV microRNA expression in a novel Indian cohort

posted Nov 25, 2016, 2:46 AM by Vaishnavi Sundar   [ updated Nov 30, 2016, 1:55 AM ]
HIV-1 replication inside host cells is known to be regulated by various host factors. Host miRNAs, by virtue of its normal functioning, also regulate HIV-1 RNA expression by either directly targeting virus mRNAs or indirectly by regulating host proteins that HIV-1 uses for own replication. Therefore, it is highly possible that with differential miRNA expression, rate of disease progression will vary in HIV-1 infected individuals. In this study we have compared expression of a panel of 13 reported anti-HIV miRNAs in human PBMCs from long term non progressors (LTNPs), regular progressors and rapid progressors.

See more at: http://www.nature.com/articles/srep28279


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